Anna FarisCindy Campbell

Simon RexGeorge

Anthony AndersonMahalik

Charlie SheenTom

Regina HallBrenda Meeks

Leslie NielsenPresident Baxter Harris

Kevin HartCJ

Jeremy PivenRoss Giggins

Pamela AndersonBecca

Jenny McCarthy-WahlbergKate

Denise RichardsAnnie

Elaine KlimaszewskiElaine

Drew MikuskaCody

Jianna BallardSue

George CarlinArchitect

Queen LatifahAunt Shaneequa / The Oracle

Eddie GriffinOrpheus

Camryn ManheimTrooper Champlin

Marny EngTabitha

Timothy StackCarson Ward

Diane KlimaszewskiDiane

Darrell HammondFather Muldoon

Dexter BellToilet Guy

Dame LeeRapper #1

Doron BellRapper #2

Simon CowellHimself

Fat JoeHimself

Ajay NaiduSayaman

William S. TaylorMr. Meeks

Patricia IdletteMrs. Meeks

David EdwardsRalph

Frank C. TurnerMr. Meek's Brother

Monica DillonBrenda's Grandmother

Lori StewartTabitha's Mother

Jim BremnerGuy in Chair

Phil DornfeldTabitha's Voice (voice)

Edward MossMJ

Dee Jay JacksonZubie

D.L. HughleyJohn Wilson

Ja RuleAgent Thompson

Macy GrayHerself

RedmanHimself

Method ManHimself

RaekwonHimself

RZAHimself

U-GodHimself

Debbie Lee CarringtonMini Tabitha

Troy YorkeAlien #1

Marco SorianoAlien #2

Cliff SolomonNative American #1

Byron Chief-MoonNative American #2

Dolly MadsenNative American #3

John HainsworthTracheotomy Man

Beverley BreuerTracheotomy Wife

Jessie YoungGirl Scout

Deanne HenryTammy Fae Baker

Eric BrekerSecret Serviceman Jones

Naomi Lawson-BairdSweet Tabitha

Abigail AdamsWedding Guest

Master PP Masters

Tom Kenny

Frank MeschkuleitAdditional Performances (puppeteer)

Derek Stephen Prince

David ZuckerDirector

Marlon WayansCharacters

Shawn WayansCharacters

Buddy JohnsonCharacters

Phil BeaumanCharacters

Jason FriedbergCharacters

Aaron SeltzerCharacters

Craig MazinScreenplay

Pat ProftScreenplay

Narges TakeshStory Editor

Robert K. WeissProducer

Andrew RonaExecutive Producer

Bob WeinsteinExecutive Producer

Harvey WeinsteinExecutive Producer

Brad WestonExecutive Producer