Wesley SnipesEric Brooks / Blade

Jessica BielAbigail Whistler

Ryan ReynoldsHannibal King

Kris KristoffersonAbraham Whistler

Dominic PurcellDracula / Drake

Parker PoseyDanica Talos

Natasha LyonneSommerfield

James RemarRay Cumberland

John Michael HigginsDr. Edgar Vance

Patton OswaltHedges

Callum Keith RennieAsher Talos

Paul Michael LévesqueJarko Grimwood

Françoise YipVirago

Mark BerryChief Martin Vreede

Paul AnthonyWolfe

Michael Anthony RawlinsWilson Hale

Ginger PageZoe

Eric BogosianBentley Tittle

Erica CerraGoth Vixen Wannabe

Clay CullenStone

Shannon PowellWoman Bystander

Kett TurtonDingo

Ron SelmourDex

Brian Steele

Scott HeindlGedge

Christopher HeyerdahlCaulder

John AshkerCampbell

Steven McMichaelDenlinger

Paul WuEllingson

Kimani Ray SmithDoh

Darren McGuireEmond

Jill KropReporter

Jordan HoffartSquid

Cascy BeddowFlick

Simon PidgeonProof

Michael St. John SmithFBI Agent

Stephen SpenderAgent

Kwesi AmeyawAgent

Alex RaeGoth Guy Wannabe

Garvin CrossHoop

Raymond SammelSecurity Guard

John UlmerSecurity Guard

Justin SainSecurity Guard

Darryl ScheelarDoctor

Camille MartinezHysterical Mother

Michelle StollVance's Assistant

Dawn ManderBiomedica Technician

David S. GoyerDirector & Writer

Marv WolfmanCharacters

Gene ColanCharacters

Peter FrankfurtProducer

Lynn HarrisProducer

Avi AradExecutive Producer

Cale BoyterExecutive Producer

Toby EmmerichExecutive Producer

Stan LeeExecutive Producer

Wesley SnipesProducer