Jennifer LopezTerri Flores

Ice CubeDanny Rich

Jon VoightPaul Serone

Eric StoltzDr. Steven Cale

Jonathan HydeWarren Westridge

Owen WilsonGary Dixon

Kari WuhrerDenise Kalberg

Vincent CastellanosMateo

Danny TrejoPoacher

Frank WelkerAnaconda (voice)

Gary A. HeckerAnaconda (voice)

Luis LlosaDirector

Jim CashAuthor

Jack Epps Jr.Author

Hans BauerAuthor

Verna HarrahProducer

Carole LittleProducer

Susan RuskinExecutive Producer

Leonard RabinowitzProducer