Sho and his friend Tetsurou stumble upon an odd alien artifact while walking through the woods. Then, the alien artifact breaks free of its metallic bonds and enters Sho's body, turning him into the Guyver. With this newfound power, Sho must battle the evil Chronos corporation and their genetically enhanced Zoanoids, who seek to retrieve the Guyver for their labs. No one close to Sho is safe from Chronos. He must fight.