Paul MercierLeon S. Kennedy (voice)

Alyson CourtClaire Redfield (voice)

Laura BaileyAngela Miller (voice)

Roger Craig SmithCurtis Miller (voice)

Crispin FreemanFrederic Downing (voice)

Michael SorichSenator Ron Davis (voice)

Salli SaffiotiIngrid Hunnigan (voice)

Michelle RuffRani Chawla (voice)

Mary Elizabeth McGlynnRani's aunt (voice)

Steve BlumGreg Glenn (voice)

Michael McConnohieWilPharma CEO (voice)

Kirk ThorntonU.S. President (voice)

Cindy RobinsonVarious (voice)

Dave WittenbergVarious (voice)

Kari WahlgrenVarious (voice)

Kyle HebertVarious (voice)

Barbara GoodsonVarious (voice)

Keith SilversteinVarious (voice)

Yuri LowenthalVarious (voice)

Megan HollingsheadVarious (voice)

Skip StellrechtVarious (voice)

Troy BakerVarious (voice)

Karen StrassmanVarious (voice)

JB BlancVarious (voice)

Johnny Yong BoschVarious (voice)

Derek MearsGreg Glenn / G-Curtis (motion capture)

Makoto KamiyaDirector

Shoutarou SugaScreenplay

Hiroyuki KobayashiStory

Yoshiaki HirabayashiStory