Grieving the loss of his wife, David Reynolds takes his family to her remote village in Colombia for healing. After a car accident, they seek shelter at a secluded inn, where they discover a young girl, Ana Maria, imprisoned and surrounded by cryptic symbols. Believing her mistreated, they free her—only to unleash a centuries-old spirit that possesses people and turns them against each other. As the entity spreads through his family, David must find a way to contain the evil before it consumes them all.